01
Choosing a medication
Semaglutide vs tirzepatide: how they differ and what the research found.
Compare your optionsYour next chapter,
better informed.
GLP-1 weight loss, explained plainly. Understand your options, know what to expect, and make sense of the research.
Sourced from FDA labels, clinical trials, and manufacturers.
Find your starting point
A clearer place to start.
02
What to expect
The first few months, dose schedules, and common side effects.
Read the month-by-month guide03
Cost & access
Understand current self-pay prices, straight from manufacturers.
Explore costsThe research, in perspective.
Published trial averages, with the context that matters.
| Trial | Medication | Average weight change | Duration |
|---|---|---|---|
| STEP 1 | Semaglutide 2.4 mg | −14.9% | 68 weeks |
| STEP UP | Semaglutide 7.2 mg | −18.8% | 72 weeks |
| SURMOUNT-1 | Tirzepatide 15 mg | −20.9% | 72 weeks |
| SURMOUNT-5 | Tirzepatide vs semaglutide | −20.2% vs −13.7% | 72 weeks |
Separate trials have different populations and methods. These are averages, not predictions. Individual results vary widely. Participants also received diet and activity counseling. Follow each trial link for sources and context.
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